- From San Francisco International Airport SFO (approximately 30 miles):
Take Highway 101 South to Great America Parkway and turn left. Hyatt Regency Santa Clara is located on the right at the corner of Tasman and Great America Parkway.
- From Norman Y. Mineta San Jose International Airport SJC (approximately 5 miles):
Turn left onto Airport Boulevard, and then turn left again onto Guadalupe Parkway. Follow the signs to Highway 101 North. Guadalupe Parkway will put you onto Highway 101 North. Take Great America Parkway and turn right.
- From Points North:
Take I-880 South and exit to Highway 237 West toward Mountain View. Turn left onto Great America Parkway, and then turn left into the hotel entrance. Hyatt Regency Santa Clara is located at the corner of Tasman and Great America Parkway.
- From Points South:
Take I-880 North to Highway 101 North and exit at Great America Parkway. Turn right onto Great America Parkway. Hyatt Regency Santa Clara is located on the corner of Tasman and Great America Parkway.
- From Points East:
Take I-5 South toward San Francisco / Los Angeles. Merge onto I-205 West toward I-580 / San Francisco; I-205 becomes I-580 West. Take the I-680 North exit toward Sacramento / San Jose, then merge onto I-680 South via the exit on the left toward San Jose. Take the Mission Boulevard West exit toward I-880 / Warm Springs District / UC Extension. Merge onto Mission Boulevard / CA-262 West, then merge onto I-880 South toward San Jose. Merge onto CA-237 West / Aliviso-Milipitas Road toward Mountain View. Take the Great America Parkway exit toward Lafayette Street, turn left onto Great America Parkway.
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